Nrf2 Breast Cancer. … Nous voudrions effectuer une description ici mais le site que

… Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. This study was aimed to determine how overexpressed wild-type HRAS …. NRF2 axis is a cellular protector signaling… Meanwhile, the dual functions of Nrf2 in cancer have been profoundly elucidated, and the Nrf2 signaling pathway has become an important therapeutic target for treating cancers, neurodegenerative diseases and … Specifically, we highlight the advances in the understanding of the mechanism of NRF2 activation, its upstream and downstream signaling and dysregulation in cancer as well … Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. Metastatic breast cancer is one of … However, the mechanisms linking gain of NRF2 expression and poor prognosis in breast cancer are still unclear. However, permanent activation of Nrf2 promotes various cancer … Here, we show that exposure of triple-negative breast cancer (TNBC) cells to ionizing radiation (IR) upregulates Nrf2 expression and promotes its nuclear translocation in a reactive … Cancer cells use the antioxidant ability of p53 against OS. These findings suggest that luteolin treatment significantly attenuated the hallmarks of breast cancer stemness by downregulating Nrf2-mediated expressions. In the present review, the potential involvement of oxidative stress and NRF2 in breast cancer will be reviewed, and the role of the NRF2 modulators—namely, polyphenols and melatonin—in … In this review, we focused on various functions of the Nrf2 pathway, including a comprehensive explanation of its role in the expansion of cancer cells, and introduced some inhibitors of this pathway into the … In summary, The NRF2 signaling pathway has been found to have both positive and negative effects on cancer growth in various types of cancer, including breast cancer. miR-200a regulates NRF2 activation by targeting KEAP1 mRNA in breast cancer … However, the mechanisms linking gain of NRF2 expression and poor prognosis in breast cancer are still unclear. MiRNA-mediated regulation of the Nrf2 signaling pathway has been shown to have … Taken together, this review aims to discuss the NRF2 multifaceted roles in both cancer prevention and promotion while also addressing the advantages, disadvantages, and … Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. Thus, NRF2 expression could be a marker for the prognostic of breast cancer patients and, in the … Dysregulation is associated with chemoresistance and radioresistance in cancerous cells. Breast cancer is the most frequently diagnosed malignant tumor in women and a major public health concern. In this respect, mounting … Taken together, this review aims to discuss the NRF2 multifaceted roles in both cancer prevention and promotion while also addressing the advantages, disadvantages, and limitations associated … In particular, the implication of NRF2 signaling in cancer stem cells (CSCs), a small population of tumor cells responsible for therapy resistance and tumor relapse, is … Taraxerol induces ferroptosis in breast cancer by targeting the transcription factor Nrf2 to regulate the E3 ubiquitin ligase MIB2, promoting the ubiquitination and degradation of … Nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of critical antioxidant proteins, was recently demonstrated to play a key role in cancer … Abstract. Paradoxically, cancer cells hijack Nrf2 signaling, and Nrf2 activators turn out to accelerate tumor progression and metastasis in mice [11 - 13]. We discuss the various molecular mechanisms interlinking the circadian rhythm with the Nrf2 pathway and contributing to breast cancer pathogenesis and whether this interplay can be exploited to overcome … Transient Nrf2 activation, by its specific activators, has protective roles against carcinogenesis and cancer development. TNBC is defined by … These results indicate that nuclear NRF2 protein plays important roles in the proliferation and/or progression of breast carcinoma, and nuclear NRF2 immunoreactivity is therefore considered a potent prognostic factor … New insights into the control of the pivotal stressregulated transcription factor NRF2 in cancer suggest new biomarkers for prognosis and treatment. Therefore, in the present study, we discussed function of Nrf2 and p53 in breast cancer (BC) cells to elucidate their role … Here, we provided evidence that the expression of xCT, the light chain subunit of system xc−, is regulated by NRF2 in representative human breast cancer cells. Here, we provide evidence that NRF2 deletion inhibits proliferation and metastasis of breast cancer … Consequently, the inhibition of Nrf2 signaling could greatly strengthen the efficacy of ferroptosis inducers in cancer cells and has been proposed as a viable strategy for cancer therapy [12]. A total of 5443 breast cancer patients with transcriptomic profile were … Triple-negative breast cancer (TNBC) is one of the most common malignant tumor types in females and its drug resistance is a major clinical issue. Nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor … NRF2 is associated with tumor recurrence, metastasis and poor prognosis in patients with NRF2-high cancers, which can include colorectal, esophageal, lung, ovarian, … NRF2 expression significantly correlated with area under the curve (AUC) of several drug response in multiple ER-positive breast cancer cell lines, however, there was no significant association between NRF2 … The complex role of NRF2 in the context of cancer continues to evolve. It is noteworthy that the NRF2/KEAP1 signaling pathway has previously been shown to play a critical role in tumorigenesis and the correlation between redox and metabolism in cancer [12]. Cytoprotective role of Keap1-Nrf2. Furthermore, the activity and protein levels of … Of these miRNAs, only miR-200a definitively activates NRF2 signaling in breast cancer cells; consequently, a careful examination of miRNAs regulating KEAP1 expression in … This review focused on Nrf2 modulators and their roles in sensitizing breast cancer cells to chemo/radiotherapy agents. The in vivo mouse model also demonstrated that the chemical inhibition of Nrf2 can increase cisplatin (CDDP) cytotoxicity. NRF2 axis is a cellular protector signaling… The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Overexpression of miR-181c in breast cancer cells blocked HIF-1α accumulation and diminished hypoxia-inducible levels of glycolysis enzymes, whereas the inhibition of miR-181c … Keap1-Nrf2 signaling pathway, as a typical antioxidant stress pathway, is abnormal in a variety of human malignant tumor diseases (such as lung cancer, liver cancer, and thyroid cancer). It accounts for … In the present review, the potential involvement of oxidative stress and NRF2 in breast cancer will be reviewed, and the role of the NRF2 modulators—namely, polyphenols and melatonin—in the treatment of … Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. It is unclear whether NRF2 suppresses or promotes breast cancer progression. Together, … Moreover, NRF2-silenced ADR44P cells displayed tumor growth retardation and reduced colony/sphere formation and invasion capacity. In recent years, … Nuclear factor erythroid-2 related factor-2 (Nrf2) is an oxidative stress-response transcriptional activator that promotes carcinogenesis through metabolic reprogramming, tumor promoting … The clinical relevance of Nuclear factor erythroid 2-Related Factor 2 (NRF2) in human breast cancer remains unclear. Due to its regulatory role in the expression of numerous cytoprotective genes involved in the antioxidant and anti-inflammatory responses, the modulation of NRF2 seems to … Radiation is widely used for cancer treatment but the radioresistance properties of cancer stem cells (CSCs) pose a significant challenge to the success of cancer therapy. 3% of patient samples … NRF2 is a transcription factor serving as a master regulator of the expression of many genes involved in cellular responses to oxidative and other stresses. Indeed, by increasing the expression of several cytoprotective genes, the … Indeed, oxidative stress is related to the triggering of cancer, so the antioxidant effect of NRF2 may play a tumor suppressor effect and is associated with chemoprevention. Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, India Breast cancer is the second leading cancer among all types of cancers. Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & endorses … Moreover, this increase in Nrf2 activity provides important protection to breast cancer cells during glucose deprivation, since siRNA knockdown of Nrf2 markedly impairs … Nuclear factor erythroid 2–related factor 2 (NRF2) has emerged as a master regulator of cellular redox homeostasis and metabolic reprogramming in cancer. The effect of NRF2 … High aerobic glycolysis not only provides energy to breast cancer cells, but also supports their anabolic growth. The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated protein 1 and nuclear factor erythroid 2–related factor 2 (NRF2) signaling pathway in 6. Nrf2 is a cellular protector, and this principle applies to both … Purpose Nuclear factor E2-related factor 2 (NRF2) is a transcription factor that plays a major role in the regulation of intracellular antioxidant response. Consistently, a set of … Ginkgetin enhances breast cancer radiotherapy sensitization by suppressing NRF2-HO-1 axis activity Qiong Duan a 1 , Zhenting Cui a 1 , Mingxiao Wang b 1 , Ruochen Li b , … We demonstrate the establishment of a distinct redox profile of breast cancer cells in the Nrf2 −/− TME when compared to WT TME. Here, we investigated the mechanisms associated with … Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous group of tumors. Constitutive activation of NRF2 is a common event in cancer and recent advances provide remarkable insights into the role of NRF2 in oncogenesis, immune evasion, and treatment resistance. In the absence of stress, NRF2 is constantly synthesized but maintained … Background Nrf2 regulates oxidative stress, which is essential for cellular function. In this review, we summarize the … Nrf2 is a transcription factor that stimulates the expression of genes which have antioxidant response element-like sequences in their promoter. Hydrogen … Thus, these data suggest that NRF2 might also play a key role in the development and progression of hormone-related cancers, such as breast, prostate, and ovarian cancer. In this … Abnormal metabolism of tumour cells is closely related to the occurrence and development of breast cancer, during which the expression of NF‐E2‐related factor 2 (Nrf2) is of great significance. An increasing number of long non … Breast cancer is the most frequently diagnosed malignant tumor in women and a major public health concern. … The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer (BC) that accounts for approximately 15% of all invasive BCs [1]. Nuclear factor … The Nrf2-overexpressing also confers chemo-resistant MCF7 cells under normoxia. Nrf2 is significantly involved in inducing antioxidant … NFE2-related factor 2 (NRF2) has apparently contradictory roles in cancer. Though recognized originally as a target of chemopreventive compounds that help … Background: Cancer and fibroadenoma are the most common breast tumors in women of reproductive age. As a transcription factor, NRF2 regulates various genes involved in redox homeo… Objectives: Previous studies described the prognostic significance of nuclear factor erythroid 2-related factor 2 (Nrf2) in breast cancers. Nuclear factor erythroid-2-related factor 2 … Abstract Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. We studied the clinical relevance of … Radiation is widely used for cancer treatment but the radioresistance properties of cancer stem cells (CSCs) pose a significant challenge to the success of cancer therapy. The activation of Nrf2 signaling induces ARE-dependent expression of … Research Paper Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway Pengfei … 6 Department of Medical Oncology, First Affiliated Hospital, Zhejiang University, Hangzhou, China NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we found that NRF2 and HIF1α mRNA and protein levels … Taken together, these findings suggest that reaching an optimal balance between paradoxical functions of Nrf2 in malignancy may render a selective improvement to identify … Considering the dual role of Nrf2 in suppressing or expanding cancer cells, determining its inhibitory/stimulatory position and targeting can represent an impressive role in … Nrf2 activation regulates a plethora of processes inducing cellular proliferation, differentiation and death, and is strongly associated with OS-mediated cancer. Luteolin constitutes a potential agent for use in … Human breast cancer cell lines-derived xenograft tumor explants assay was used to evaluate the compound’s efficacy and to assess the induction of methuosis via NRF2 activation by tanshinlactone. It is unclear whether NRF2 could promote breast cancer cell growth through enhancing glycolysis. What’s more, Nrf2 activation is also involved in anti … The elevation of glycolysis, activation of epithelial-mesenchymal transition (EMT), and inhibition of ferroptosis are additional features of NRF2 upregulation in human cancers. Wnt signaling is aberrantly activated in many cancers, such as colorectal cancer and invasive ductal breast cancer, and its activation induces the conversion of dormant CSCs to active CSCs through β-catenin-mediated … These results suggest that tumours that overexpress NRF2 have a worse clinical outcome. In order to develop effective therapeutic strategies, it is therefore essential to identify the subtype … For example, in breast cancer, miR-28 regulates NRF2 expression through a KEAP1-independent mechanism (29). It maintains the redox homeostasis, … In this article, we have discussed the attributes associated with Nrf2 in the development of drug resistance, angiogenesis, cancer stem cell generation, and metastasis in … Background Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we provide evidence that NRF2 deletion inhibits … More importantly, NRF2 can be upregulated by multiple anticancer drugs, suggesting a role of NRF2 in the immediate and reversible drug tolerant state and in the … NRF2 status was significantly associated with BCRP (Breast Cancer Resistance Protein) and marginally associated with LRP (Lung-resistance-related Protein) … Breast cancer is the most frequently diagnosed malignant tumor in women and a major public health concern. In line with these, CD44 significantly … Recently, Douglas B Fox and colleagues also discovered that the activation of NRF2 can promote the recurrence of dormant breast cancer cells by inducing metabolic … The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage induced by exogenous chemicals. Activation of NRF2 contributes to the chemopreventive effects of various clinically used drugs … Overexpression of miR-181c in breast cancer cells blocked HIF-1α accumulation and diminished hypoxia-inducible levels of glycolysis enzymes, whereas the inhibition of miR-181c in NRF2 … Depletion of NRF2 increased basal levels of reactive oxygen species (ROS) and severely reduced ability to form primary tumors and lung metastases. While … Nuclear factor erythroid 2-related factor 2 (NRF2) is a key modifier in breast cancer. The redox sensitive transcription factor NRF2 is over-expressed in multiple … Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. NRF2 axis is a cellular protector signaling pathway protecting both normal and … In our study, decreased expression of GSK-3β was observed in the cancer tissues of breast cancer patients, results of immunohistochemistry indicated that Nrf2 was highly … HRAS is often overactivated in breast cancer, whereas mutations are rare in this malignancy. vpjoobfd
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